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1996-02-27
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Document 0006
DOCN M9630006
TI Somatic symptoms and HIV infection: relationship to depressive symptoms
and indicators of HIV disease.
DT 9603
AU Perkins DO; Leserman J; Stern RA; Baum SF; Liao D; Golden RN; Evans DL;
Department of Psychiatry, University of North Carolina School of;
Medicine, Chapel Hill 27599-7160, USA.
SO Am J Psychiatry. 1995 Dec;152(12):1776-81. Unique Identifier : AIDSLINE
MED/96080014
AB OBJECTIVE: This study examined the relationship of the somatic symptoms
fatigue and insomnia with indicators of both psychiatric disturbance and
HIV disease severity. METHOD: Study participants were 98 asymptomatic
HIV-infected and 71 uninfected homosexual men; 82 HIV-infected and 64
uninfected men had 6-month follow-up examinations. Scales from the
self-reported Profile of Mood States measured fatigue and dysphoric
mood. Major depression diagnosis was determined by the Structured
Clinical Interview for DSM-III-R. Selected items from the Hamilton
depression and anxiety scales measured insomnia and other symptoms of
depression. Performance on a battery of standardized tests determined
neuropsychological function ratings. RESULTS: At study entry, complaints
of fatigue and insomnia were associated with dysphoric mood, major
depression, and other non-HIV-related symptoms of major depression but
not with CD4 cell counts or neuropsychological functioning. Increases in
levels of fatigue and insomnia over the 6-month follow-up period were
associated with increases in non-HIV-related symptoms of depression and
in severity of dysphoric mood. Increases in fatigue were also associated
with decrements in motor functioning. Otherwise, fatigue or insomnia
were not associated with HIV disease progression. CONCLUSIONS: These
findings suggest that complaints of fatigue and insomnia in otherwise
asymptomatic HIV-infected patients are likely to be related to
psychological disturbances and possibly major depression, which can be
treated. HIV-infected patients who complain of fatigue or insomnia
should routinely be assessed for major depression.
DE Adult Comorbidity CD4 Lymphocyte Count Depressive
Disorder/*DIAGNOSIS/EPIDEMIOLOGY Fatigue/*DIAGNOSIS/EPIDEMIOLOGY
Follow-Up Studies Homosexuality, Male/PSYCHOLOGY Human HIV
Infections/*DIAGNOSIS/PSYCHOLOGY Insomnia/*DIAGNOSIS/EPIDEMIOLOGY Male
Neuropsychological Tests Personality Inventory Prevalence Psychiatric
Status Rating Scales Regression Analysis Severity of Illness Index
Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).